The crash happened a along 8th Avenue just south of Lake Michigan Drive around 12:30 p.m.
A black car pulled out of a driveway and was struck on the driver’s side by a white minivan traveling south on 8th Avenue.
A male driver and female passenger in the car were transported to the hospital with serious injuries. A 16-year-old girl in the back seat of the van was also taken to the hospital and is in serious condition, according to Ottawa County officials.
Firefighters that responded have since cleared the scene, while officers remain on scene to conduct their investigation.