The Ohio native has served the Cleveland area since he became a priest in 1979.
Walkowiak will lead 82 parishes, 30 schools and 182,000 Roman Catholics in West Michigan. He replaces Bishop Walter Hurley, who has served the Grand Rapids Diocese for the past eight years.
Walkowiak will be installed during a mass at 2 p.m. at the Cathedral of St. Andrew. It is also his 60th birthday.
The ceremony will be streamed live on fox17online.com.