According to the Battle Creek Police Department, the crash happened in the 2300 block of Meachem Road, just west of M-37 in Bedford Township just after 6:30 a.m.
When Police arrived on scene, officers found that one person was ejected from the vehicle and three more people were trapped inside the vehicle.
Police say the driver of the vehicle lost control on the curve and hit two trees.
Aeromed was called to the scene and took the two survivors to Bronson Hospital in Kalamazoo.
The accident remains under investigation.