Indiana State Police tell FOX 17 that the accident is near Michigan City, Indiana. According to our sister station WGN in Chicago, at least three people are confirmed dead and at least 20 others were injured.
The crash is located near mile marker 33 from US 421 to US 35.
It is not clear how many vehicles are involved; however, pictures from people in the area show more than a dozen semi trucks possibly involved in the chain-reaction crash.
Photos from the FOX 17 Facebook (click to enlarge):